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pentobarbital will reduce the level or effect of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Pitolisant exposure is lessened by fifty% if coadministered with powerful CYP3A4 inducers.pentobarbital will lessen the extent or influence of erlotinib by influencing hepatic/intestinal enzyme CYP3A